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Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains.

Yang Z, Wang C, Zhou Q, An J, Hildebrandt E, Aleksandrov LA, Kappes JC, DeLucas LJ, Riordan JR, Urbatsch IL, Hunt JF, Brouillette CG,
Protein Science (2014) 23:769-89 PublishedPSI:Biology  
Northeast Structural Genomics Consortium
24652590  
PMC4093953  
10.1002/pro.2460  
10 (Last update: 03/25/2017 12:20:19pm)  
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