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Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.

Aiyer S, Swapna GV, Malani N, Aramini JM, Schneider WM, Plumb MR, Ghanem M, Larue RC, Sharma A, Studamire B, Kvaratskhelia M, Bushman FD, Montelione GT, Roth MJ,
Nucleic Acids Research (2014) 42:5917-28 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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We report alterations to the murine leukemia virus (MLV) integrase (IN) protein that successfully result in decreasing its integration frequency at transcription start sites and CpG islands, thereby reducing the potential for insertional activation. ...
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