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Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.

Lavery LA, Partridge JR, Ramelot TA, Elnatan D, Kennedy MA, Agard DA,
Molecular Cell (2014) 53:330-43 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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While structural symmetry is a prevailing feature of homo-oligomeric proteins, asymmetry provides unique mechanistic opportunities. ...
24462206  
PMC3947485  
10.1016/j.molcel.2013.12.023  
39 (Last update: 09/16/2017 11:37:40am)  
structure