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The physical state of lipid substrates provides transacylation specificity for tafazzin.

Schlame M, Acehan D, Berno B, Xu Y, Valvo S, Ren M, Stokes DL, Epand RM,
Nature Chemical Biology (2012) 8:862-9 PublishedPSI:Biology  
Transcontinental EM Initiative for Membrane Proteins

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Cardiolipin is a mitochondrial phospholipid with a characteristic acyl chain composition that depends on the function of tafazzin, a phospholipid-lysophospholipid transacylase, although the enzyme itself lacks acyl specificity. ...
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