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Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.

Richter F, Blomberg R, Khare SD, Kiss G, Kuzin AP, Smith AJ, Gallaher J, Pianowski Z, Helgeson RC, Grjasnow A, Xiao R, Seetharaman J, Su M, Vorobiev S, Lew S, Forouhar F, Kornhaber GJ, Hunt JF, Montelione GT, Tong L, Houk KN, Hilvert D, Baker D,
Journal of the American Chemical Society (2012) 134:16197-206 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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Nucleophilic catalysis is a general strategy for accelerating ester and amide hydrolysis. ...
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