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Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.

Pastore C, Topalidou I, Forouhar F, Yan AC, Levy M, Hunt JF,
Journal of Biological Chemistry (2012) 287:2130-43 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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Humans express nine paralogs of the bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkylation damage to nucleobases. ...
chemistry physiology metabolism 
Crystallography, X-Ray tRNA Methyltransferases Protein Structure, Tertiary Humans RNA Processing, Post-Transcriptional RNA, Transfer Substrate Specificity Amino Acid Motifs Catalysis 
22065580  
PMC3265892  
10.1074/jbc.M111.286187  
33 (Last update: 05/27/2017 11:46:48am)  
3THP
3THT  
structure