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Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.

Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM,
Proceedings of the National Academy of Sciences of the United States of America (2011) 108:18678-83 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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Peroxisome proliferator activated receptor (PPAR) γ coactivator-1α (PGC-1α) is a potent transcriptional coactivator of oxidative metabolism and is induced in response to a variety of environmental cues. ...
chemistry methods metabolism 
Models, Molecular Protein Structure, Tertiary Humans Mitochondria Transcription Factors Protein Conformation Transcription, Genetic Receptors, Estrogen Ligands Oxygen X-Rays Protein Binding Heat-Shock Proteins Biophysics Molecular Conformation Scattering, Radiation 
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