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Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.

Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM,
Proceedings of the National Academy of Sciences of the United States of America (2011) 108:18678-83 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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Peroxisome proliferator activated receptor (PPAR) γ coactivator-1α (PGC-1α) is a potent transcriptional coactivator of oxidative metabolism and is induced in response to a variety of environmental cues. ...
metabolism chemistry methods 
Humans Protein Structure, Tertiary Models, Molecular Protein Binding Molecular Conformation Protein Conformation X-Rays Heat-Shock Proteins Ligands Transcription Factors Transcription, Genetic Receptors, Estrogen Scattering, Radiation Oxygen Mitochondria Biophysics 
22049338  
10.1073/pnas.1113813108  
32 (Last update: 09/15/2018 3:52:03pm)  
structure