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Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.

Chang A, Singh S, Helmich KE, Goff RD, Bingman CA, Thorson JS, Phillips GN,
Proceedings of the National Academy of Sciences of the United States of America (2011) 108:17649-54 PublishedPSI:Biology  
Center for Eukaryotic Structural GenomicsEnzyme Discovery for Natural Product Biosynthesis

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Glycosyltransferases are useful synthetic catalysts for generating natural products with sugar moieties. ...
metabolism chemistry methods genetics biosynthesis 
Protein Engineering Aminoglycosides Carbohydrates Enediynes Protein Interaction Domains and Motifs Glycosyltransferases Antibiotics, Antineoplastic Hydroxylamines 
21987796  
PMC3203770  
10.1073/pnas.1108484108  
25 (Last update: 12/08/2018 12:22:47pm)  
3OTG
3OTH
3OTI
3RSC  
structure