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Novel C-terminal Motif within Sec7 Domain of Guanine Nucleotide Exchange Factors Regulates ADP-ribosylation Factor (ARF) Binding and Activation.

Lowery J, Szul T, Seetharaman J, Jian X, Su M, Forouhar F, Xiao R, Acton TB, Montelione GT, Lin H, Wright JW, Lee E, Holloway ZG, Randazzo PA, Tong L, Sztul E,
Journal of Biological Chemistry (2011) 286:36898-906 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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ADP-ribosylation factors (ARFs) and their activating guanine nucleotide exchange factors (GEFs) play key roles in membrane traffic and signaling. ...
metabolism chemistry genetics 
Humans Protein Structure, Tertiary Amino Acid Motifs Catalysis Amino Acid Substitution Guanosine Triphosphate HeLa Cells Mutation, Missense Guanine Nucleotide Exchange Factors ADP-Ribosylation Factors GTPase-Activating Proteins Guanosine Diphosphate 
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