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Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus.

Guan R, Ma LC, Leonard PG, Amer BR, Sridharan H, Zhao C, Krug RM, Montelione GT,
Proceedings of the National Academy of Sciences of the United States of America (2011) 108:13468-73 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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Interferon-induced ISG15 conjugation plays an important antiviral role against several viruses, including influenza viruses. ...
metabolism chemistry pharmacology 
Binding Sites Crystallography, X-Ray Humans Protein Binding Cytokines Ubiquitins Viral Nonstructural Proteins Influenza B virus Protein Interaction Domains and Motifs Interferons 
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