View publication

Structure of the guanylyltransferase domain of human mRNA capping enzyme.

Chu C, Das K, Tyminski JR, Bauman JD, Guan R, Qiu W, Montelione GT, Arnold E, Shatkin AJ,
Proceedings of the National Academy of Sciences of the United States of America (2011) 108:10104-8 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

(click to unfold)
The enzyme guanylyltransferase (GTase) plays a central role in the three-step catalytic process of adding an (m7)GpppN cap cotranscriptionally to nascent mRNA (pre-mRNAs). ...
chemistry genetics 
Crystallography, X-Ray Protein Structure, Tertiary Humans Molecular Sequence Data Fungal Proteins Animals DNA Mutational Analysis Binding Sites Nucleotidyltransferases 
21636784  
PMC3121809  
10.1073/pnas.1106610108  
14 (Last update: 07/15/2017 11:45:40am)  
structure