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Improved molecular replacement by density- and energy-guided protein structure optimization.

DiMaio F, Terwilliger TC, Read RJ, Wlodawer A, Oberdorfer G, Wagner U, Valkov E, Alon A, Fass D, Axelrod HL, Das D, Vorobiev SM, Iwaï H, Pokkuluri PR, Baker D,
Nature (2011) 473:540-3 PublishedPSI:Biology  
Joint Center for Structural GenomicsNortheast Structural Genomics Consortium

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Molecular replacement procedures, which search for placements of a starting model within the crystallographic unit cell that best account for the measured diffraction amplitudes, followed by automatic chain tracing methods, have allowed the rapid solution of large numbers of protein crystal structures. ...
chemistry methods 
Computational Biology Crystallography, X-Ray Models, Molecular Databases, Protein Sequence Alignment Electrons Proteins Sequence Homology, Amino Acid Structural Homology, Protein 
21532589  
10.1038/nature09964  
122 (Last update: 03/18/2017 12:18:26pm)  
Improved molecular replacement by density- and energy-guided protein structure optimization
 
method