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Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors.

You L, Cho EJ, Leavitt J, Ma LC, Montelione GT, Anslyn EV, Krug RM, Ellington A, Robertus JD,
Accounts of Chemical Research (2011) 21:3007-11 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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A library of quinoxaline derivatives were prepared to target non-structural protein 1 of influenza A (NS1A) as a means to develop anti-influenza drug leads. ...
antagonists & inhibitors chemical synthesis chemistry pharmacology drug effects 
Molecular Structure Nuclear Proteins Enzyme Activation Quinoxalines Humans Structure-Activity Relationship Transcription Factors Enzyme Inhibitors Viral Nonstructural Proteins Inhibitory Concentration 50 
21478016  
PMC3114437  
10.1016/j.bmcl.2011.03.042  
25 (Last update: 04/01/2017 12:04:44pm)  
structure