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A de novo protein binding pair by computational design and directed evolution.

Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione GT, Spiegel CP, Liu DR, Baker D,
Molecular Cell (2011) 42:250-60 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein-protein interactions and would enable unique approaches to biological and medical challenges. ...
chemistry genetics metabolism 
Models, Molecular Protein Interaction Domains and Motifs Molecular Weight Mutation Protein Conformation Protein Interaction Mapping Protein Multimerization Binding Sites Computer-Aided Design Proteins Chemistry Techniques, Analytical Protein Binding Surface Properties 
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