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A de novo protein binding pair by computational design and directed evolution.

Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione GT, Spiegel CP, Liu DR, Baker D,
Molecular Cell (2011) 42:250-60 PublishedPSI:Biology  
Northeast Structural Genomics Consortium

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The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein-protein interactions and would enable unique approaches to biological and medical challenges. ...
metabolism chemistry genetics 
Binding Sites Models, Molecular Protein Binding Proteins Protein Conformation Mutation Molecular Weight Surface Properties Protein Interaction Mapping Chemistry Techniques, Analytical Computer-Aided Design Protein Multimerization Protein Interaction Domains and Motifs 
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