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Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems.

Arbing MA, Handelman SK, Kuzin AP, Verdon G, Wang C, Su M, Rothenbacher FP, Abashidze M, Liu M, Hurley JM, Xiao R, Acton T, Inouye M, Montelione GT, Woychik NA, Hunt JF,
Structure (2010) 18:996-1010 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Bacterial toxin-antitoxin (TA) systems serve a variety of physiological functions including regulation of cell growth and maintenance of foreign genetic elements. ...
chemistry antagonists & inhibitors 
Crystallography, X-Ray Models, Molecular Computational Biology Escherichia coli Proteins Protein Conformation Structure-Activity Relationship Evolution, Molecular Phylogeny Viral Proteins Shigella flexneri Bacterial Toxins Bacteriophage P1 Escherichia coli K12 
43 (Last update: 03/16/2019 12:28:53pm)