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Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems.

Arbing MA, Handelman SK, Kuzin AP, Verdon G, Wang C, Su M, Rothenbacher FP, Abashidze M, Liu M, Hurley JM, Xiao R, Acton T, Inouye M, Montelione GT, Woychik NA, Hunt JF,
Structure (2010) 18:996-1010 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Bacterial toxin-antitoxin (TA) systems serve a variety of physiological functions including regulation of cell growth and maintenance of foreign genetic elements. ...
chemistry antagonists & inhibitors 
Bacteriophage P1 Computational Biology Crystallography, X-Ray Models, Molecular Phylogeny Bacterial Toxins Structure-Activity Relationship Protein Conformation Evolution, Molecular Shigella flexneri Escherichia coli Proteins Viral Proteins Escherichia coli K12 
36 (Last update: 04/21/2018 11:44:59am)