View publication

Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA.

Arragain S, Handelman SK, Forouhar F, Wei FY, Tomizawa K, Hunt JF, Douki T, Fontecave M, Mulliez E, Atta M,
Journal of Biological Chemistry (2010) 285:28425-33 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

(click to unfold)
Bacterial and eukaryotic transfer RNAs have been shown to contain hypermodified adenosine, 2-methylthio-N(6)-threonylcarbamoyladenosine, at position 37 (A(37)) adjacent to the 3'-end of the anticodon, which is essential for efficient and highly accurate protein translation by the ribosome. ...
analogs & derivatives metabolism enzymology chemistry genetics 
Escherichia coli Mice Amino Acid Sequence Adenosine Bacterial Proteins Heat-Shock Proteins Sulfurtransferases Cyclin-Dependent Kinase 5 Escherichia coli Proteins Archaea Sequence Analysis, Protein Bacillus subtilis Humans Molecular Sequence Data RNA, Transfer Threonine Animals 
20584901  
PMC2937867  
10.1074/jbc.M110.106831  
57 (Last update: 07/22/2017 11:25:23am)  
structure