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Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA.

Arragain S, Handelman SK, Forouhar F, Wei FY, Tomizawa K, Hunt JF, Douki T, Fontecave M, Mulliez E, Atta M,
Journal of Biological Chemistry (2010) 285:28425-33 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Bacterial and eukaryotic transfer RNAs have been shown to contain hypermodified adenosine, 2-methylthio-N(6)-threonylcarbamoyladenosine, at position 37 (A(37)) adjacent to the 3'-end of the anticodon, which is essential for efficient and highly accurate protein translation by the ribosome. ...
analogs & derivatives genetics metabolism enzymology chemistry 
Bacillus subtilis Escherichia coli Humans Molecular Sequence Data RNA, Transfer Threonine Animals Mice Amino Acid Sequence Adenosine Bacterial Proteins Heat-Shock Proteins Sulfurtransferases Cyclin-Dependent Kinase 5 Escherichia coli Proteins Archaea Sequence Analysis, Protein 
20584901  
PMC2937867  
10.1074/jbc.M110.106831  
48 (Last update: 03/18/2017 11:44:29am)  
structure