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Computational design of a PAK1 binding protein.

Jha RK, Leaver-Fay A, Yin S, Wu Y, Butterfoss GL, Szyperski T, Dokholyan NV, Kuhlman B,
Journal of Molecular Biology (2010) 400:257-70 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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We describe a computational protocol, called DDMI, for redesigning scaffold proteins to bind to a specified region on a target protein. ...
chemistry genetics 
Models, Molecular Computer Simulation Humans Molecular Sequence Data Protein Conformation Sequence Alignment Molecular Dynamics Simulation Amino Acid Sequence Software Nuclear Magnetic Resonance, Biomolecular Protein Binding p21-Activated Kinases 
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