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Computational design of a PAK1 binding protein.

Jha RK, Leaver-Fay A, Yin S, Wu Y, Butterfoss GL, Szyperski T, Dokholyan NV, Kuhlman B,
Journal of Molecular Biology (2010) 400:257-70 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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We describe a computational protocol, called DDMI, for redesigning scaffold proteins to bind to a specified region on a target protein. ...
chemistry genetics 
Humans Amino Acid Sequence Models, Molecular Molecular Sequence Data Protein Binding Sequence Alignment Protein Conformation Software Nuclear Magnetic Resonance, Biomolecular Computer Simulation Molecular Dynamics Simulation p21-Activated Kinases 
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