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Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein.

Aramini JM, Tubbs JL, Kanugula S, Rossi P, Ertekin A, Maglaqui M, Hamilton K, Ciccosanti CT, Jiang M, Xiao R, Soong TT, Rost B, Acton TB, Everett JK, Pegg AE, Tainer JA, Montelione GT,
Journal of Biological Chemistry (2010) 285:13736-41 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Alkyltransferase-like proteins (ATLs) are a novel class of DNA repair proteins related to O(6)-alkylguanine-DNA alkyltransferases (AGTs) that tightly bind alkylated DNA and shunt the damaged DNA into the nucleotide excision repair pathway. ...
metabolism chemistry genetics enzymology physiology analogs & derivatives 
Humans Protein Folding DNA Amino Acid Substitution DNA Repair Guanine Mutation, Missense Alkyl and Aryl Transferases Vibrio parahaemolyticus 
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