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Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein.

Aramini JM, Tubbs JL, Kanugula S, Rossi P, Ertekin A, Maglaqui M, Hamilton K, Ciccosanti CT, Jiang M, Xiao R, Soong TT, Rost B, Acton TB, Everett JK, Pegg AE, Tainer JA, Montelione GT,
Journal of Biological Chemistry (2010) 285:13736-41 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Alkyltransferase-like proteins (ATLs) are a novel class of DNA repair proteins related to O(6)-alkylguanine-DNA alkyltransferases (AGTs) that tightly bind alkylated DNA and shunt the damaged DNA into the nucleotide excision repair pathway. ...
analogs & derivatives metabolism enzymology chemistry physiology genetics 
DNA DNA Repair Amino Acid Substitution Humans Alkyl and Aryl Transferases Protein Folding Guanine Mutation, Missense Vibrio parahaemolyticus 
20212037  
PMC2859536  
10.1074/jbc.M109.093591  
12 (Last update: 03/25/2017 11:24:44am)  
structure