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Protein secondary structure appears to be robust under in silico evolution while protein disorder appears not to be.

Schaefer C, Schlessinger A, Rost B,
Bioinformatics (2010) 26:625-631 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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MOTIVATION: The mutation of amino acids often impacts protein function and structure. ...
chemistry methods 
Computational Biology Databases, Protein Protein Folding Protein Structure, Secondary Amino Acid Sequence Proteins 
20081223  
10.1093/bioinformatics/btq012  
29 (Last update: 05/27/2017 12:09:27pm)  
method