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Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage.

Prysak MH, Mozdzierz CJ, Cook AM, Zhu L, Zhang Y, Inouye M, Woychik NA,
Molecular Microbiology (2009) 71:1071-87 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Toxin-antitoxin (TA) systems on the chromosomes of free-living bacteria appear to facilitate cell survival during intervals of stress by inducing a state of reversible growth arrest. ...
metabolism genetics 
Antitoxins Bacterial Toxins Escherichia coli Ribosomes RNA, Messenger Endoribonucleases Substrate Specificity RNA, Bacterial Peptide Chain Elongation, Translational RNA Stability Escherichia coli Proteins 
19210620  
10.1111/j.1365-2958.2008.06572.x  
77 (Last update: 04/01/2017 12:12:22pm)  
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