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Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase.

Legler PM, Kumaran D, Swaminathan S, Studier FW, Millard CB,
Biochemistry (2008) 47:9592-601 PublishedPSI:Phase 2  
New York Structural Genomics Research Consortium

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Saccharomyces cerevisiae expresses a 67.8 kDa homodimeric serine thioesterase, S-formylglutathione hydrolase (SFGH), that is 39.9% identical with human esterase D. ...
physiology genetics metabolism enzymology chemistry 
Cholinesterase Inhibitors Crystallography, X-Ray Paraoxon Protein Structure, Tertiary Saccharomyces cerevisiae Proteins Amino Acid Substitution Humans Thiolester Hydrolases Hydrolysis Saccharomyces cerevisiae Phosphorylation Binding Sites Carboxylesterase Sequence Homology, Amino Acid Drug Resistance, Fungal Mutation, Missense 
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