View publication

Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.

Khan JA, Forouhar F, Tao X, Tong L,
Expert opinion on therapeutic targets (2007) 11:695-705 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

(click to unfold)
Nicotinamide adenine dinucleotide (NAD(+)) has crucial roles in many cellular processes, both as a coenzyme for redox reactions and as a substrate to donate ADP-ribose units. ...
drug therapy antagonists & inhibitors metabolism pharmacology therapeutic use physiology drug effects 
DNA Damage Signal Transduction Clinical Trials, Phase II as Topic Kynurenine Piperidines Tryptophan Acrylamides Neoplasms Neuroprotective Agents Mice Neurodegenerative Diseases Aging Autoimmune Diseases Poly Adenosine Diphosphate Ribose Sirtuins Drug Design NAD Humans Enzyme Inhibitors Adenosine Diphosphate Ribose Animals Cyclic ADP-Ribose Antineoplastic Agents 
17465726  
10.1517/14728222.11.5.695  
93 (Last update: 04/01/2017 11:29:55am)  
2QL6
2QG6  
structure