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Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB.

Yu B, Edstrom WC, Benach J, Hamuro Y, Weber PC, Gibney BR, Hunt JF,
Nature (2006) 439(7078):879-84 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Nucleic acid damage by environmental and endogenous alkylation reagents creates lesions that are both mutagenic and cytotoxic, with the latter effect accounting for their widespread use in clinical cancer chemotherapy. ...
chemistry metabolism enzymology 
Crystallography, X-Ray DNA Models, Molecular DNA Repair Escherichia coli Mixed Function Oxygenases Oxidation-Reduction Protein Conformation Pliability Alkylation Binding Sites RNA Catalysis Hydrogen Bonding Escherichia coli Proteins Anaerobiosis 
16482161  
10.1038/nature04561  
140 (Last update: 04/01/2017 11:57:37am)  
2FD8
2FDF
2FDG
2FDH
2FDI
2FDJ
2FDK  
structure  
multiple pdbids [2fdf,2fdi]