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Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB.

Yu B, Edstrom WC, Benach J, Hamuro Y, Weber PC, Gibney BR, Hunt JF,
Nature (2006) 439(7078):879-84 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Nucleic acid damage by environmental and endogenous alkylation reagents creates lesions that are both mutagenic and cytotoxic, with the latter effect accounting for their widespread use in clinical cancer chemotherapy. ...
metabolism chemistry enzymology 
Binding Sites Crystallography, X-Ray Hydrogen Bonding Models, Molecular Escherichia coli Oxidation-Reduction Escherichia coli Proteins Mixed Function Oxygenases Catalysis Protein Conformation RNA DNA Pliability DNA Repair Alkylation Anaerobiosis 
16482161  
10.1038/nature04561  
150 (Last update: 12/08/2018 7:33:43pm)  
2FD8
2FDF
2FDG
2FDH
2FDI
2FDJ
2FDK  
structure  
multiple pdbids [2fdf,2fdi]