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A method using active-site sequence conservation to find functional shifts in protein families: application to the enzymes of central metabolism, leading to the identification of an anomalous isocitrate dehydrogenase in pathogens.

Das R, Gerstein M,
Proteins (2004) 55(2):455-63 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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We have introduced a method to identify functional shifts in protein families. ...
chemistry metabolism 
Phylogeny Conserved Sequence Humans Isocitrate Dehydrogenase Molecular Sequence Data Sequence Alignment Animals Citric Acid Cycle Binding Sites Malate Dehydrogenase Amino Acid Sequence Amino Acid Motifs Succinate Dehydrogenase 
15048835  
10.1002/prot.10639  
4 (Last update: 03/25/2017 12:15:45pm)  
method  
Proteins. 2004 May 1;55(2):455-63.