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A method using active-site sequence conservation to find functional shifts in protein families: application to the enzymes of central metabolism, leading to the identification of an anomalous isocitrate dehydrogenase in pathogens.

Das R, Gerstein M,
Proteins (2004) 55(2):455-63 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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We have introduced a method to identify functional shifts in protein families. ...
metabolism chemistry 
Binding Sites Humans Amino Acid Motifs Amino Acid Sequence Animals Conserved Sequence Molecular Sequence Data Sequence Alignment Phylogeny Succinate Dehydrogenase Citric Acid Cycle Isocitrate Dehydrogenase Malate Dehydrogenase 
4 (Last update: 03/16/2019 6:00:32pm)  
Proteins. 2004 May 1;55(2):455-63.