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Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode.

Chien CY, Xu Y, Xiao R, Aramini JM, Sahasrabudhe PV, Krug RM, Montelione GT,
Biochemistry (2004) 43(7):1950-62 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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The influenza virus nonstructural protein 1 encoded by influenza A virus (NS1A protein) is a multifunctional protein involved in both protein-protein and protein-RNA interactions. ...
metabolism chemistry isolation & purification 
Protein Structure, Tertiary Protein Binding RNA-Binding Proteins Chromatography, Gel Nuclear Magnetic Resonance, Biomolecular Ultracentrifugation Protons Carbon Isotopes Nitrogen Isotopes Circular Dichroism Peptide Fragments Thermodynamics RNA, Viral Viral Nonstructural Proteins Influenza A virus RNA, Double-Stranded DNA, Viral Epitope Mapping Nucleic Acid Heteroduplexes 
14967035  
10.1021/bi030176o  
86 (Last update: 12/08/2018 12:09:05pm)  
method  
Biochemistry. 2004 Feb 24;43(7):1950-62.