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Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain.

Jogl G, Shen Y, Gebauer D, Li J, Wiegmann K, Kashkar H, Krönke M, Tong L,
EMBO Journal (2002) 21(18):4785-95 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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The BEACH domain is highly conserved in a large family of eukaryotic proteins, and is crucial for their functions in vesicle trafficking, membrane dynamics and receptor signaling. ...
metabolism chemistry physiology genetics 
Crystallography, X-Ray Signal Transduction Protein Structure, Tertiary Intracellular Signaling Peptides and Proteins Mice Binding Sites Protein Structure, Secondary Amino Acid Sequence Carrier Proteins Nerve Tissue Proteins Models, Molecular Humans Molecular Sequence Data Recombinant Fusion Proteins Sequence Alignment Chediak-Higashi Syndrome Animals Membrane Proteins Proteins Protein Binding 
12234919  
10.1093/emboj/cdf502  
59 (Last update: 04/01/2017 12:16:10pm)  
1MI1  
structure  
EMBO J. 2002 Sep 16;21(18):4785-95.