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Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain.

Jogl G, Shen Y, Gebauer D, Li J, Wiegmann K, Kashkar H, Krönke M, Tong L,
EMBO Journal (2002) 21(18):4785-95 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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The BEACH domain is highly conserved in a large family of eukaryotic proteins, and is crucial for their functions in vesicle trafficking, membrane dynamics and receptor signaling. ...
metabolism chemistry genetics physiology 
Binding Sites Crystallography, X-Ray Humans Protein Structure, Tertiary Amino Acid Sequence Animals Models, Molecular Molecular Sequence Data Nerve Tissue Proteins Protein Binding Protein Structure, Secondary Proteins Sequence Alignment Signal Transduction Intracellular Signaling Peptides and Proteins Membrane Proteins Carrier Proteins Mice Recombinant Fusion Proteins Chediak-Higashi Syndrome 
12234919  
10.1093/emboj/cdf502  
62 (Last update: 11/17/2018 9:54:50pm)  
1MI1  
structure  
EMBO J. 2002 Sep 16;21(18):4785-95.