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Loopy proteins appear conserved in evolution.

Liu J, Tan H, Rost B,
Journal of Molecular Biology (2002) 322:53-64 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Over the last decade, structural biologists have unravelled many proteins that appear natively disordered. ...
analysis classification metabolism chemistry methods 
Amino Acids Proteome Conserved Sequence Databases, Protein Structure-Activity Relationship Evolution, Molecular Transcription, Genetic Pliability Protein Folding Protein Structure, Secondary Proteins Protein Binding Hydrogen Bonding Solvents Computational Biology Models, Molecular 
140 (Last update: 03/25/2017 11:39:58am)  
J Mol Biol. 2002 Sep 6;322(1):53-64.