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Protein solubility and folding monitored in vivo by structural complementation of a genetic marker protein.

Wigley WC, Stidham RD, Smith NM, Hunt JF, Thomas PJ,
Nature Biotechnology (2001) 19(2):131-6 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Protein misfolding is the basis of a number of human diseases and presents an obstacle to the production of soluble recombinant proteins. ...
chemistry genetics metabolism 
Genes, Reporter Cystic Fibrosis Transmembrane Conductance Regulator Humans Solubility Mutagenesis, Site-Directed Recombinant Fusion Proteins Genetic Markers Protein Folding Amyloid beta-Peptides beta-Galactosidase Peptide Fragments 
120 (Last update: 07/22/2017 11:49:08am)  
Nat Biotechnol. 2001 Feb;19(2):131-6.