View publication

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.

Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L,
Nature (2000) 408(6808):111-5 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

(click to unfold)
Toll-like receptors (TLRs) and the interleukin-1 receptor superfamily (IL-1Rs) are integral to both innate and adaptive immunity for host defence. ...
chemistry metabolism 
Crystallography, X-Ray Drosophila Proteins Toll-Like Receptors Protein Structure, Tertiary Protein Conformation Receptors, Cell Surface Mice Receptors, Interleukin-1 Amino Acid Sequence Toll-Like Receptor 4 Models, Molecular Humans Molecular Sequence Data Recombinant Fusion Proteins Structure-Activity Relationship Cloning, Molecular Animals Toll-Like Receptor 2 Point Mutation Membrane Glycoproteins Toll-Like Receptor 1 Drosophila Protein Binding 
11081518  
10.1038/35040600  
510 (Last update: 03/25/2017 12:27:13pm)  
1FYV
1FYW
1FYX  
structure  
Nature. 2000 Nov 2;408(6808):111-5.