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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.

Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L,
Nature (2000) 408(6808):111-5 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Toll-like receptors (TLRs) and the interleukin-1 receptor superfamily (IL-1Rs) are integral to both innate and adaptive immunity for host defence. ...
metabolism chemistry 
Crystallography, X-Ray Humans Protein Structure, Tertiary Amino Acid Sequence Animals Drosophila Proteins Models, Molecular Molecular Sequence Data Protein Binding Cloning, Molecular Protein Conformation Structure-Activity Relationship Mice Recombinant Fusion Proteins Point Mutation Membrane Glycoproteins Receptors, Cell Surface Drosophila Receptors, Interleukin-1 Toll-Like Receptor 1 Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors 
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10.1038/35040600  
530 (Last update: 11/10/2018 5:01:37pm)  
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Nature. 2000 Nov 2;408(6808):111-5.