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Measuring shifts in function and evolutionary opportunity using variability profiles: a case study of the globins.

Naylor GJ, Gerstein M,
Journal of Molecular Evolution (2000) 51:223-33 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Variability profiles measured over a set of aligned sequences can be used to estimate evolutionary freedom to vary. ...
chemistry physiology genetics 
Models, Molecular Phylogeny Humans Hemoglobins Globins Evolution, Molecular Animals Protein Subunits Myoglobin Genetic Variation 
31 (Last update: 04/21/2018 6:06:18pm)  
J Mol Evol. 2000 Sep;51(3):223-33.