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Measuring shifts in function and evolutionary opportunity using variability profiles: a case study of the globins.

Naylor GJ, Gerstein M,
Journal of Molecular Evolution (2000) 51:223-33 PublishedPSI:Phase 2  
Northeast Structural Genomics Consortium

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Variability profiles measured over a set of aligned sequences can be used to estimate evolutionary freedom to vary. ...
chemistry genetics physiology 
Humans Animals Models, Molecular Hemoglobins Protein Subunits Evolution, Molecular Globins Phylogeny Myoglobin Genetic Variation 
11029067  
10.1002/prot.24227  
31 (Last update: 05/23/2018 11:09:17pm)  
method  
J Mol Evol. 2000 Sep;51(3):223-33.