|Genome Research (2002) 12(3):503-14|
|Midwest Center for Structural Genomics|
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We present a novel web-based resource, Gene3D, of precalculated structural assignments to gene sequences and whole genomes. ...
This resource assigns structural domains from the CATH database to whole genes and links these to their curated functional and structural annotations within the CATH domain structure database, the functional Dictionary of Homologous Superfamilies (DHS) and PDBsum. Currently Gene3D provides annotation for 36 complete genomes (two eukaryotes, six archaea, and 28 bacteria). On average, between 30% and 40% of the genes of a given genome can be structurally annotated. Matches to structural domains are found using the profile-based method (PSI-BLAST). and a novel protocol, DRange, is used to resolve conflicts in matches involving different homologous superfamilies.
|genetics statistics & numerical data |
|Protein Structure, Tertiary Animals Databases, Protein Proteins Software Bacterial Proteins Archaeal Proteins Genes, Bacterial Genome, Bacterial Genome Sequence Homology, Nucleic Acid Internet Genes Databases, Genetic Genome, Archaeal Genes, Archaeal |
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