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Efficient recognition of protein fold at low sequence identity by conservative application of Psi-BLAST: application.

Stevens FJ, Kuemmel C, Babnigg G, Collart FR,
Journal of Molecular Recognition (2005) 18(2):150-7 PublishedPSI:Phase 2  
Midwest Center for Structural Genomics

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Based on a study involving structural comparisons of proteins sharing 25% or less sequence identity, three rounds of Psi-BLAST appear capable of identifying remote evolutionary homologs with greater than 95% confidence provided that more than 50% of the query sequence can be aligned with the target sequence. ...
chemistry methods 
Binding Sites Humans Algorithms Amino Acid Sequence Animals Databases, Protein Models, Molecular Molecular Sequence Data Protein Structure, Secondary Proteins Computational Biology Sequence Alignment Protein Folding Sequence Homology, Amino Acid Software Evolution, Molecular Genome Sequence Analysis, Protein 
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