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High-resolution structure of the nitrile reductase QueF combined with molecular simulations provide insight into enzyme mechanism.

Kim Y, Zhou M, Moy S, Morales J, Cunningham MA, Joachimiak A,
Journal of Molecular Biology (2010) 404:127-37 PublishedPSI:Biology  
Midwest Center for Structural Genomics

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Here, we report the 1.53-Å crystal structure of the enzyme 7-cyano-7-deazaguanine reductase (QueF) from Vibrio cholerae, which is responsible for the complete reduction of a nitrile (CN) bond to a primary amine (H(2)C-NH(2)). ...
chemistry metabolism enzymology 
Crystallography, X-Ray Models, Molecular Protein Structure, Tertiary NADP Molecular Dynamics Simulation Nitriles Oxidoreductases Protein Binding Vibrio cholerae 
20875425  
10.1016/j.jmb.2010.09.042  
19 (Last update: 01/14/2017 11:57:27am)  
3BP1  
26423  
structure