Wladek Minor, Ph.D.
Professor

US Mail Address:
Department of Molecular Physiology
and Biological Physics
University of Virginia
PO Box 800736
Charlottesville, VA 22908-0736

Our laboratory studies macromolecular structure with an aim toward in-depth understanding of structure-function relationships. X-ray diffraction analysis is our primary research tool, but we also employ other physical and biochemical methods of analysis. The program emphasizes two broad themes: crystallographic studies on molecules of immediate interest, and methodology development. Most of the macromolecules that we have under study relate to one or more of a few broad biological areas: cellular signal transduction and metalloproteins. The same systems have been chosen as subjects for methodology development. The methodology development includes the development of various crystallographic tools that create the HKL package. Another research area is high-throughout crystallography and structural genomics. Our lab is a member of the Midwestern Center for Structural Genomics Consortium and the Center for Structural Genomics of Infectious Diseases. We develop high-throughput crystallography equipment - integrated system for data collection and analysis has been installed at X9B beamline at NSLS.

SAD/MAD Recent Structures

Lab Members: Maksymilian Chruszcz, Instructor, maks@iwonka.med.virginia.edu Marcin Cymborowski, Research Assistant, marcel@iwonka.med.virginia.edu Ekaterina Filippova, Postdoctoral Research Associate, katya@iwonka.med.virginia.edu Marek Grabowski, Postdoctoral Research Associate, marek@iwonka.med.virginia.edu Dominik Gront, Postdoctoral Fellow, dominik@iwonka.med.virginia.edu Olga Kirillova, Postdoctoral Research Associate, olga@iwonka.med.virginia.edu Aleksandra Knapik, Visiting Graduate Student, aleksandra@iwonka.med.virginia.edu Janusz Petkowski, Graduate Student, janusz@iwonka.med.virginia.edu John Raynor, Research Assistant, john@iwonka.med.virginia.edu Igor Shumilin, Instructor, ias2n@virginia.edu Shuren Wang, Research Assistant, shuren@iwonka.med.virginia.edu Heping Zheng, Graduate Student, dust@virginia.edu Matt Zimmerman, Postdoctoral Fellow, MZimmerman@virginia.edu

Recent Events:

	ISGO Meeting, Beijing, October 2006
	GetPhases Meeting, Beijing, October 2005
	Hans Deisenhofer visit, UVA, September 2005
	IUCr Meeting, Florence, August 2005
	Department Holiday Party, UVA, December 2003
	Lab Holiday Party, UVA, December 2003
	EBI Meeting, Cambridge, March 2003

 

Selected Publications:

Tong L, Choi HK, Minor W, Rossman MG  (1992)
The Structure Determination Of Sindbis Virus Core Protein Using Isomorphous Replacement And Molecular Replacement Averaging Between 2 Crystal Forms
Acta Crystallographica. Section A: Foundations of Crystallography 48 ( Pt 4): 430-42. (Pub Med ID: 1418825)
Times cited: 15

Otwinowski Z, Borek D, Majewski W, Minor W  (2003)
Multiparametric scaling of diffraction intensities
Acta Crystallographica. Section A: Foundations of Crystallography 59: 228-34. (Pub Med ID: 12714773)
Times cited: 130

Chruszcz M, Cymborowski M, Gawlicka-chruszcz A, Yasukawa S, Ferrara JD, Minor W  (2004)
L-methioninium Chloride and L-selenomethioninium Chloride at 103 K
Acta Crystallographica Section C: Crystal Structure Communications 60: o868-71. (Pub Med ID: 15579969)
Times cited: 0

Borek D, Minor W, Otwinowski Z  (2003)
Measurement errors and their consequences in protein crystallography
Acta Crystallographica. Section D: Biological Crystallography 59: 2031-8. (Pub Med ID: 14573959)
Times cited: 11

Minor W, Steczko J, Bolin JT, Otwinowski Z, Axelrod B  (1993)
Crystallographic Determination Of The Active-Site Iron And Its Ligands In Soybean Lipoxygenase L-1
Biochemistry 32: 6320-3. (Pub Med ID: 8518276)
Times cited: 112

Tomchick DR, Phan P, Cymborowski M, Minor W, Holman TR  (2001)
Structural and functional characterization of second-coordination sphere mutants of soybean lipoxpgenase-1
Biochemistry 40: 7509-17. (Pub Med ID: 11412104)
Times cited: 51

Otwinowski Z, Minor W  (2006)
Denzo and Scalepack
International Tables For Crystallography, Volume F 

Otwinowski Z, Minor W  (1997)
Processing of X-ray diffraction data collected in oscillation mode
Methods in Enzymology 275: 307-326. 
Times cited: 16853

Minor W, Otwinowski Z  (1996)
Advances in Accuracy and Automation of Data Collection and Processing
Proceedings Of Iucr Computing School 

O'Toole N, Grabowski M, Otwinowski Z, Minor W, Cygler M  (2004)
The structural genomics experimental pipeline: Insights from global target lists
Proteins 56: 201-10. (Pub Med ID: 15211505)
Times cited: 19

Minor W, Tomchick DR, Otwinowski Z  (2000)
Strategies for macromolecular synchrotron crystallography
Structure 8: R105-10. (Pub Med ID: 10801499)
Times cited: 29

More publications with external links are available.

Last updated: Sunday 03rd of February 2008 10:28:03 AM
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